Archive for the ‘Vitamin D’ Category

h1

Vitamin D Prevents Systemic Inflammation to Keep Chronic Diseases in Check

December 3, 2012
Vitamin D Prevents Systemic Inflammation to Prevent Chronic Diseases

Vitamin D Prevents Systemic Inflammation to Prevent Chronic Diseases

The connection between cellular saturation of the prohormone, vitamin D and development of chronic conditions ranging from cancer, dementia, stroke and heart disease have been well documented among forward-thinking scientists for at least a decade now. The specific mechanism of action has not been well documented though, as most studies have not drawn a clear line between blood levels of vitamin D and disease prevention.

High Vitamin D Status Inhibits Inflammatory Messengers to Prevent Chronic Disease

High Vitamin D Status Inhibits Inflammatory Messengers to Prevent Chronic Disease

High Vitamin D Status Inhibits Inflammatory Messengers to Prevent Chronic Disease

Researchers from National Jewish Health reporting in The Journal of Immunology have discovered specific molecular and signaling events by which vitamin D inhibits inflammation to help prevent and possibly even treat a host of potentially deadly diseases. Current levels considered satisfactory by most medical professionals did not inhibit the inflammatory cascade, leading to the progression of many forms of disease. Conversely, individuals that maintain significantly higher blood levels of vitamin D had lower levels of inflammatory markers known to aggravate disease progression and were protected against the major killers so prevalent today.

The study author, Dr. Elena Goleva noted that this research “goes beyond previous associations of vitamin D with various health outcomes. It outlines a clear chain of cellular events, from the binding of DNA, through a specific signaling pathway, to the reduction of proteins known to trigger inflammation.” Current guidelines call for minimum vitamin D blood serum levels of 20 ng/ml, a benchmark set decades ago that was intended to prevent rickets in children and promote bone health. Researchers conducting this study found improvement in inflammation levels at a minimum of 30 ng/ml. leaving millions at risk for chronic disease.

Check Vitamin D Blood Levels Every Six Months to Prevent Inflammation

Check Vitamin D Blood Levels Every Six Months to Prevent Inflammation

Check Vitamin D Blood Levels Every Six Months to Prevent Inflammation

Scientists conducting this study examined the specific mechanisms exhibited by vitamin D to act on immune and inflammatory pathways. They incubated white blood cells with different saturation levels of vitamin D and then exposed the culture to an inflammatory molecule known to promote intense inflammatory responses. Cells exposed to low levels of vitamin D (less than 15 ng/ml) produced excessive levels of the inflammatory cytokines IL-6 and TNF-alpha, associated with disease development and progression. The highest level of inflammatory inhibition occurred at 50 ng/ml and above as cells become fully saturated with the prohormone and maximum immune response is observed.

Researchers identified a new location where the vitamin-D receptor appears to bind directly to DNA and activate a gene known as MKP-1, interfering with the inflammatory cascade promoted by long-term stress and a highly refined, processed food diet. Dr. Goleva concluded “The fact that we showed a dose-dependent and varying response to levels commonly found in humans also adds weight to the argument for vitamin D’s role in immune and inflammatory conditions.” Maintain your vitamin D blood levels above 50 ng/ml (measured with the 25(OH)D test) to afford maximum protection against chronic inflammatory-mediated diseases.

h1

Vitamin D Lowers Systemic Inflammation to Decrease Heart Disease Risk

September 10, 2012
Vitamin D Dramatically Lowers Heart Disease Risk

Vitamin D Dramatically Lowers Heart Disease Risk

Thousands of research studies have demonstrated the powerful health-promoting properties of the prohormone compound, vitamin D3. Researchers publishing in The Journal of Immunology explain the specific molecular and signaling events by which vitamin D inhibits inflammation in the human body. In a very detailed analysis, scientists show that low blood circulating levels of vitamin D do not adequately inhibit the inflammatory cascade necessary to turn off this potentially destructive mechanism.

Low levels of inflammation, normally used by the body to fight pathogenic invaders, become a primary cause of heart disease, diabetes, many cancer lines and Alzheimer’s dementia.  Additional evidence reported in the British Journal of Nutrition demonstrates that adequate vitamin D levels reduce critical markers of cardiovascular health and can lead to significant reductions in body fat in overweight and obese people. It is critical to have your vitamin D level checked, and supplement as necessary to lower inflammation levels and risk of heart disease.

Vitamin D Lowers Inflammation to Prevent Chronic Disease and Stimulate Immune Response Systems

Vitamin D From Gelcaps Reduces Metabolic Inflammation

Vitamin D From Gelcaps Reduces Metabolic Inflammation

Dr. Elena Goleva, lead scientist from National Jewish Health, found that prior studies with vitamin D show a clear and positive link between blood levels of the prohormone and a variety of different health outcomes. Dr. Goleva and her team looked for specific mechanisms to explain precisely how vitamin D functions at the cellular level to prevent disease in the human body.

Dr. Goleva and her team of researchers noted that vitamin D is a catalyst that initiates “a clear chain of cellular events, from the binding of DNA, through a specific signaling pathway, to the reduction of proteins known to trigger inflammation.”  To test how vitamin D acts on immune and inflammatory pathways, team scientists exposed human white blood cells to varying levels of vitamin D and exposed them to an agent known to promote intense inflammatory responses and advance disease processes.

Vitamin D Lowers Inflammatory Markers and Increases Health-Promoting HDL Cholesterol

Vitamin D Improves the Immune Capacity of White Blood Cells

Vitamin D Improves the Immune Capacity of White Blood Cells

White blood cells that were incubated with no vitamin D or a solution of 15 ng/mL produced very high levels of the pro-inflammatory cytokines IL-6 and TNF-alpha. In vivo, these signaling messengers are known to be responsible for the development and progression of cardiovascular disease, certain forms of cancer and dementia. Cells incubated at a concentration of 30 ng/mL and above showed a significantly reduced response, while the highest level of inflammatory inhibition occurred at 50 ng/ml.

Supporting evidence for the health-promoting effect of vitamin D as reported in the journal BMJ shows marked improvement in cardiovascular biomarkers including HDL cholesterol. Additionally, researchers found the hormone-like substance lowered the risk of lipid peroxidation, the process responsible for making LDL cholesterol molecules sticky and prone to form atherosclerotic plaque. They also determined that high circulating levels of vitamin D were associated with “significant reductions in fat mass” in overweight and obese people.

There should be no doubt that the millions of people living with grossly sub-optimal vitamin D levels are dramatically increasing their risk of developing a plethora of potentially deadly illnesses. Health-minded individuals will ensure they maintain a circulating blood level of 50 to 70 ng/mL by means of a 25(OH)D blood test to regulate systemic inflammation and fight chronic disease.

h1

Vitamin D Helps Prevent Heart Disease, Dementia and Diabetes

August 27, 2012
Vitamin D Supplements Prevent Chronic Diseases

Vitamin D Supplements Prevent Chronic Diseases

Scientific research bodies extolling the amazing virtues of the prohormone, vitamin D have been published in rapid succession to explain the preventive mechanism shown to prevent cardiovascular disease, diabetes and Alzheimer’s disease. Three independent reviews demonstrate that maintaining a vitamin D blood level between 50 and 70 ng/mL can provide optimal protection against many chronic diseases.

Researchers’ publishing in the journal Nutrition, Metabolism & Cardiovascular Diseases provide evidence that vitamin D is intrinsically involved in the homeostasis of the cardiovascular system. Disruption of the body’s natural stasis system contributes to diabetes, obesity, elevated blood lipids, high blood pressure, endothelial dysfunction, stroke and risk of coronary artery disease. Scientists advise supplementation of 4,000 to 8,000 IU of vitamin D per day to achieve optimal levels, far above the anemic 400 IU currently recommended.

Vitamin D Controls Genetic Receptors to Guard against Chronic Disease

Vitamin D is Shown to Work at the Genetic Level to Halt Heart Disease

Vitamin D is Shown to Work at the Genetic Level to Halt Heart Disease

Scientists at the University of Miami’s School of Medicine demonstrate a direct genetic link between low vitamin D levels and the development of amyloid proteins in the brain, commonly associated with Alzheimer’s disease. Reporting in the journal Neurobiology of Aging, researchers looked at gene signaling in relation to the vitamin D receptor in 492 late onset Alzheimer’s patients and 496 control subjects.

When vitamin D receptors were not activated on the surface of individual cells due to poor vitamin D saturation in the blood, precise gene signaling went awry that halted normal clearance of the dementia-related protein clumps. The team conducting the study concluded “Our findings are consistent with epidemiology studies suggesting that vitamin D insufficiency increases the risk of developing Alzheimer’s disease.”

Test Vitamin D Blood Levels Regularly to Ensure Optimal Range

Test Vitamin D Blood Levels Regularly to Achieve Optimal Disease Protection

Test Vitamin D Blood Levels Regularly to Achieve Optimal Disease Protection

Researchers in Spain evaluated the vitamin D status of 1,226 individuals in 1996. The participants were again tested eight years later, and vitamin D levels were contrasted with development of diabetes over the course of the study. The results, published in the journal Clinical Nutrition, found that those with vitamin D blood levels above 18.5 ng/mL had an 83 percent lower risk of developing type 2 diabetes during the eight year period. No one in the study with a vitamin D score over 30 ng/mL developed type 2 diabetes.

It has become very clear from countless research studies published over the past decade that vitamin D qualifies among the most crucial and essential hormone-based nutrients. And still millions of people continue to place themselves at unnecessary risk by ignoring this information.

Most people above the age of twenty-one should supplement with a minimum of 2,000 IU of vitamin D every day and have their blood tested to ensure they reach the optimal range of 50 to 70 ng/mL. Extensive research provides more than sufficient evidence that maintaining a proper vitamin D level can dramatically lower the risk of heart disease, Alzheimer’s disease diabetes and many other chronic illnesses.

h1

Low Vitamin D Levels Associated with Childhood Diabetes Spike

May 7, 2012
Excess Weight in Children Lowers Vitamin D and Raises Diabetes Risk

Excess Weight in Children Lowers Vitamin D and Raises Diabetes Risk

Researchers publishing in The Journal of Clinical Endocrinology and Metabolism have found that children with low vitamin D levels, especially when overweight and obese, are at much higher risk for developing insulin resistance progressing to full-blown diabetes by early adulthood. Based on cellular saturation of the vitamin/prohormone, children and adults require higher amounts of vitamin D as body weight increases.

The vast majority of children are vitamin D deficient, a problem exacerbated further by additional fat stores. In addition to a healthy lifestyle including plenty of physical activity and proper diet, parents will want to ensure their children reach proper blood levels of this critical vitamin through exposure to the sun or adequate supplementation.

Low Vitamin D Levels Lead to Insulin Resistance and Diabetes in Overweight Children

Declining insulin Sensitivity Affects Vitamin D Blood Saturation

Declining insulin Sensitivity Affects Vitamin D Blood Saturation

Past research studies have concluded that high rates of vitamin D insufficiency are found most prominently in overweight and obese populations and are linked to dramatically increased risk of heart disease and diabetes. These studies have not explained the mechanism by which excess fat stores and low vitamin D saturation result in chronic disease development and progression.

Dr. Micah Olson and his team from The University of Texas Southwestern Medical Center examined the association between vitamin D levels and dietary habits in 498 obese and non-obese children. The researchers checked for levels of abnormal glucose metabolism and blood pressure in the participants. Additionally, the scientists measured vitamin D levels, blood sugar levels, serum insulin and BMI. Study participants were also asked to provide dietary information including daily intake of soda, juice and milk, average daily fruit and vegetable intake, and whether or not they routinely skipped breakfast.

Children with Higher Soda and Juice Consumption Showed Lower Vitamin D Levels

Higher Soda Consumption Directly Correlated with Lower Vitamin D Levels in Children

Higher Soda Consumption Directly Correlated with Lower Vitamin D Levels in Children

The study authors determined that 92% of the obese children tested had a vitamin D saturation (using the standard 25(OH)D test) below the ‘adequate’ level of 30 ng/mL. 50% of the participants were classified as ‘deficient’ with a level below 20 ng/mL. Dr. Olson commented “Poor dietary habits such as skipping breakfast and increased soda and juice intake were associated with the lower vitamin D levels seen in obese children.” The study concluded that obese children with low serum blood levels of vitamin D had higher degrees of insulin resistance that played a significant role in the development of Type II diabetes.

New cases of diabetes and prediabetes are now found in young adults and even children at an alarming and increasing rate. This research highlights the connection between low vitamin D levels, excess body weight and diabetes risk and underscores the importance of vitamin D blood testing for all children and adults. Alternative health practitioners recommend maintaining a vitamin D level between 50 and 70 ng/mL using the 25(OH)D blood test.

h1

Vitamin D Reduces Colon Cancer Risk, Improves Mortality

November 30, 2011
The Sunshine Vitamin is Shown to Fight Cancer by Multiple Metabolic Mechanisms

The Sunshine Vitamin is Shown to Fight Cancer by Multiple Metabolic Mechanisms

Just in case you needed more proof that low blood levels of vitamin D represent a significant health concern, researchers publishing in the European Journal of Clinical Nutrition demonstrate that small increases in the sunshine vitamin can add precious years to your life. For nearly a decade scientific evidence has been mounting to show that the vast majorities of adults (and many children) are grossly deficient in circulating blood levels of vitamin D.

Further proof is documented in the PLoS One journal to show the precise cellular mechanism that helps vitamin D dramatically lower the risk of colon cancer. The bottom line is simple: check your vitamin D blood saturation with an inexpensive test and make the necessary adjustments to live a healthier and longer life.

Doubling Average Vitamin D Levels Could Cut World Death Rate by Twenty Percent

Doubling Vitamin D Levels Could Lower Worldwide Death Rate by 20%

Doubling Vitamin D Levels Could Lower Worldwide Death Rate by 20%

Using epidemiologic studies, Dr. W.B. Grant of the Sunlight, Nutrition and Health Research Center in San Francisco found that doubling the serum blood concentration of vitamin D could increase average life expectancy by two years. Dr. Grant and his team identified the major diseases that responded to increased levels of vitamin D. They then compared mortality rates to six identified regions around the country, and contrasted serum blood levels of the sunshine vitamin with disease occurrence.

After compiling all the data, the researchers found that conditions and diseases responsive to vitamin D that account for over half of the world’s mortality include cancer, cardiovascular disease, diabetes, tuberculosis, respiratory diseases and infections. It was determined that doubling the circulating level of vitamin D would lower the mortality rates of diseases that are sensitive to vitamin D by approximately 20 percent. Dr. Grant concluded “several ways to raise serum vitamin D include food fortification, supplementation and increased ultraviolet B exposure.”

Vitamin D Directly Correlated With Decreased Colon Cancer Risk

Vitamin D Supplementation Prevents DNA Mutations Leading to Colon Cancer

Vitamin D Supplementation Prevents DNA Mutations Leading to Colon Cancer

Researchers have known for some time that low vitamin D levels are associated with a significant increase in colon cancer cases, but have not understood the specific mechanism responsible. Now, scientists have discovered how a lack of vitamin D promotes DNA damage and colon cancer risk. Specifically, low vitamin D status instigates the development and progression of this devastating form of cancer.

Researchers have focused on a protein in intestinal epithelial cells called beta-catechin that normally helps epithelial cells bond together with other cells to form a protective barrier between the contents in your gut and the physical structure of your digestive tract. They found that when vitamin D is lacking, DNA synthesis is disrupted and beta-catechin builds up in cells, dramatically increasing the risk of colon cancer initiation.

There should be no doubt remaining that one of the most critical foundations to vibrant health is maintaining proper vitamin D blood saturation levels. Prevention is worth a pound of cure, so have your family physician run the simple and inexpensive 25 (OH)D blood test (alternatively, mail-in home testing is now a viable option), and be certain your level runs between 50 and 70 ng/mL to add years to your life and dramatically lower colon cancer and chronic disease risk.

h1

Resveratrol and Vitamin D Compliment Weight Management Efforts

November 28, 2011
Natural Nutrient Duo Assists Weight Loss Efforts

Natural Nutrient Duo Assists Weight Loss Efforts

Resveratrol has been on the nutritional radar of researchers because of its proven ability to mimic some of the life-extending characteristics provided by calorie restriction as seen in animals and humans alike. Scientists publishing in the journal Molecular Nutrition and Food Research draw a solid link between resveratrol, vitamin D and other phytonutrients as agents that may lend a helping hand in the life-threatening battle against overweight and obesity.

Researchers document the newly discovered effect of the nature-derived nutrient on lipid metabolism, and demonstrate that supplementation along with the sunshine vitamin and quercetin synergistically decreases the formation of new fat cells in the body. This finding is significant because it may provide a critical metabolic aid to children and adults that suffer the health-damaging effects of obesity every day. Further evidence exists to hail the trio in the genesis of osteoblasts in bone marrow that may offer a new therapy for osteoporosis that affects the mobility of millions of aging adults.

Resveratrol and Vitamin D Combine to Regulate Genes that Control Body Weight

Vitamin D Protects Against New Baby Fat Cell Formation

Vitamin D Protects Against New Baby Fat Cell Formation

Scientists studying metabolism in aging adults have found that stem cells differentiate in favor of adipocytes (fat cells) and to the exclusion of osteoblasts (cells necessary for the formation of new bone). This means that as we age, our body has evolved to store fat as an aid to our survival. As metabolism slows, we continue to eat the same number of calories that helps to fill the newly acquired adipocytes. While building and maintaining bone structure may sound like a good idea to us, it is not pre-programmed into our genetic matrix.

Development of new fat cells has evolved as a protective mechanism, although the vast majority of older adults really don`t need this genetic advantage. Researchers found that supplemented resveratrol, vitamin D and quercetin work together to regulate our genes and down regulate the production of fat cells while boosting the production of osteoblasts. Naturally it is important to practice caloric restriction as we age. Many aging adults will be able to utilize this phytonutrient trio to prevent excess weight gain and the debilitating effects of osteoporosis.

Natural Nutrients Help Weight Management Efforts Along with Healthy Diet

Resveratrol and Vitamin D Synergistically Inhibit Abdominal Adiposity

Resveratrol and Vitamin D Synergistically Inhibit Abdominal Adiposity

In addition to the well documented anti-cancer and longevity benefits previously ascribed to supplemented resveratrol, health-minded individuals will want to include resveratrol and other phytonutrients as an aid in the fight against abdominal fat accumulation. Researchers concluded It should be noted that combining resveratrol with other phytochemicals may provide an extraordinary potential for preventing obesity and osteoporosis. These phytochemical synergies may make possible novel safe, potent and efficacious therapies.” Be sure to include resveratrol (25 to 50 mg per day) in your dietary arsenal to assist weight loss, boost metabolism and prevent bone loss.

h1

Vitamin D Key to Chronic Disease Prevention

October 26, 2011
Vitamin D, the Sunshine Vitamin is Essential to Prevent Chronic Illness

Vitamin D, the Sunshine Vitamin is Essential to Prevent Chronic Illness

Prominent research studies continue to extol the virtues of maintaining proper levels of critical nutrients such as vitamin D throughout life to prevent most diseases that plaque western cultures. Publishing in the European Journal of Clinical Nutrition scientists found that by simply raising the low end of the vitamin D blood saturation range (from 30 ng/mL to 44 ng/mL), all-cause mortality could be reduced by 7.6% to 17.3% for most women.

This supports the extensive body of work published by Dr. Bruce Ames that explains low nutritional status through life results in the development of diseases including heart disease, cancer, diabetes and dementia. A high quality multi-vitamin taken daily can provide a broad range of protection against a host of chronic illnesses.

Lower All-Cause Mortality Up to 20% for Pennies a Day

Vitamin D Deficiency Leads to a 20% Increased Mortality Rate

Vitamin D Deficiency Leads to a 20% Increased Mortality Rate

If you found out that you could lower your risk of dying by as much as 20% simply by increasing vitamin D intake, would you be willing to make the change? For most people this would mean taking an additional 1500 IU of the sunshine vitamin at a daily cost of $.03. While some people can benefit directly from sun exposure, aging adults (over 50), those in Northern climates and dark-skinned individuals will need to take an oil based supplement and monitor blood levels to ensure optimal protection.

You won`t hear about results that show that increasing vitamin D intake or other essential nutrients can significantly lower your risk for developing chronic disease. The scientists performing this study on European women found “Increasing serum 25(OH)D levels is the most cost-effective way to reduce global mortality rates, as the cost of vitamin D is very low and there are few adverse effects from oral intake and/or frequent moderate UVB irradiance with sufficient body surface area exposed.”

Triage Theory Explains Long Term Nutritional Deficiency Leads to Early Death

Dr. Bruce Ames Posits the 'Triage Theory' to Explain Long-Term Nutritional Deficiency

Dr. Bruce Ames Posits the 'Triage Theory' to Explain Long-Term Nutritional Deficiency

Dr. Bruce Ames has been studying the long term effect of poor nutrition on health for more than 30 years and proposed the triage theory in 2006. The theory explains how long-term deficiency in nutrients such as vitamin D and K increase genetic mutations over time and cause diseases associated with aging like cancer, heart disease, and dementia.

Dr. Ames explains that his research demonstrates that nutritional deficiencies over the course of decades (and even short term deficits in the case of vitamin D) cause the body to promote metabolic processes that support short term survival and reproduction. Long term maintenance goals that effect repair and regeneration of genetic material including chromosomes and DNA are allowed to go unattended when adequate nutrients are lacking in cellular stores.

Very few health-minded individuals would argue against the virtue of a well-balanced and unrefined diet centered on a colorful array of vegetables, fruits, nuts, seeds and legumes. Most children and adults will want to ensure optimal intake of vitamins, minerals, fats and amino acids through a sensible approach to diet and taking a high quality whole food based multi-vitamin each day.