Archive for the ‘Resveratrol’ Category

h1

Red Grape Compound Aids Weight Loss to Help Prevent Obesity

January 15, 2013
Red Grape Compounds Aid Weight Management to Help Prevent Obesity

Red Grape Compounds Aid Weight Management to Help Prevent Obesity

Obesity and overweight are threatening the health and lives of nearly seventy percent of the US population, and indicators are this epidemic is continuing to affect even more men, women and children as it places a significant burden on an already failing health care system. Most health-minded individuals understand the importance of eliminating refined and processed foods while maintaining constant blood glucose and insulin levels to achieve individual weight management goals.

Researchers from Purdue University have published the result of a study in the Journal of Biological Chemistry that demonstrates the potent nature of natural compounds found in red wine and many fruits to block cellular processes that allow fat cells to develop. Scientists found that the compound piceatannol, found naturally in the skin of grapes and other fruits blocks an immature fat cell’s ability to develop and grow, opening a door to a potential method to control obesity.

Piceatannol Inhibits the Formation of Mature Fat Cells to Achieve Weight Management Goals

The lead study author, Dr. Kee-Hong Kim found that piceatannol, an analog of resveratrol found in grapes and other fruit, is converted to piceatannol in humans following its consumption. The team tested piceatannol in cultured immature fat cells called preadipocytes to determine if the compound inhibited the maturity process that results in fully developed fat cells, capable of storing body fat and contributing to obesity.

Dr. Kim commented “We consider that adipogenesis is an important molecular target to delay or prevent fat cell accumulation and, hopefully, body fat mass gain.” The team found that piceatannol bound to the insulin receptor on the immature fat cells, effectively blocking insulin’s ability to control normal cellular cycling resulting in mature adipocytes. The grape-derived compound stimulated the activation of special genes necessary for the fat cell maturation process.

Eat a Wide Variety of Natural Fruits and Vegetables to Help Weight Loss Issues

The study authors concluded “Piceatannol actually alters the timing of gene expressions, gene functions and insulin action during adipogenesis, the process in which early stage fat cells become mature fat cells… in the presence of piceatannol, you can see delay or complete inhibition of adipogenesis.” Similar in structure to resveratrol, scientists believe piceatannol may also exert some of the same properties to help combat cancer, heart disease and neurodegenerative conditions.

Piceatannol is yet another natural compound that has demonstrated the ability to influence genetic expression to inhibit the formation of adipocytes or alter metabolism to help achieve weight management goals alongside resveratrol, green tea catechins (EGCG) and irvingia gabonensis. When used to compliment a natural food diet void of wheat and refined carbohydrates, piceatannol may be an important component to achieve natural weight management goals.

h1

Nuts and Resveratrol Deliver a Potent Punch to Prevent Cognitive Decline and Dementia

May 17, 2012
Raw Nuts Provide Essential Fats to Prevent Cognitive Decline

Raw Nuts Provide Essential Fats to Prevent Cognitive Decline

Nuts, especially walnuts, almonds and hazelnuts, combined with the potent polyphenol resveratrol team together to improve mood and protect the aging brain to help maintain memory and cognition. Researchers reporting in the New England Journal of Medicine have found that nuts consumed over a period of years not only help with weight management issues, but also can reduce systemic inflammation to improve spirits and prevent cognitive decline.

Resveratrol has long been associated with brain health. The Journal of Pineal Research reports that resveratrol demonstrates anti-aging properties in the brain necessary for energy production and optimal brain function. Combining these two natural agents together as part of your healthy diet can improve mood, help retain memories and preserve youthful thought patterns.

Nuts Improve Mood, Slash Brain Inflammation and Prevent Cognitive Decline

Resveratrol and Nuts Lower Brain Inflammation to Improve Mood

Resveratrol and Nuts Lower Brain Inflammation to Improve Mood

Researchers determined to validate the health-promoting capacity of nuts provided test participants with a diet of walnuts, almonds and hazelnuts for a period of 12 weeks. The volunteers for this study were sex and age-matched individuals given a control diet, and compared to a group not receiving the nut mixture. All participants exhibited symptoms of metabolic syndrome, increasing risk for developing diabetes, heart disease, mood disorders and loss of cognition.

Individuals receiving the nuts had increased levels of serotonin which will help a person feel better and potentially more satisfied and less likely to suffer from depression and poor mood. Additionally, the nut control group demonstrated reduced inflammatory markers from the high polyphenol content of the nuts. This is an important finding, as individuals exhibiting the signs of metabolic syndrome experience the effects of systemic inflammation leading to accelerated brain aging and cognitive decline.

Resveratrol Positively Influences Gene Expression to Restore Mitochondria Function

Resveratrol From Red Grapes and Wine Improves Mitochondrial Function

Resveratrol From Red Grapes and Wine Improves Mitochondrial Function

Mitochondria are the tiny metabolic engines that are responsible for powering each of our trillion or so cells throughout the body. Over time, mitochondria begin to experience loss of function and cellular decline and aging of the cell begin. Mitochondrial regulation is controlled in large part by the ‘longevity’ gene known as Sirt1. Calorie restriction and potent natural nutrients such as resveratrol are known to alter expression of the Sirt1 gene. Researchers have demonstrated that resveratrol is able to restore neural mitochondria function by reviving Sirt1 gene expression, and provides “a potent anti-aging effect within the brain.”

The human brain is a highly metabolic organ, demanding 20% of the total oxygen supply for the body. As such, it is also susceptible to the effects of oxidative stress and free radical damage that cause brain inflammation and advanced signs of aging. Natural nutrients such as resveratrol (25 – 50 mg per day) that cross the blood-brain barrier and foundation monounsaturated fats supplied by most nuts (1 to 2 ounces each day) and seeds protect the brain from damage and dramatically lower the risk of memory loss and cognitive decline.

h1

Resveratrol May Help Lower Risk of Breast Cancer

January 12, 2012
Resveratrol is Shown to Halt Breast Cancer Cell Development and Migration

Resveratrol is Shown to Halt Breast Cancer Cell Development and Migration

Researchers from the Faculty of Pharmacy at the University of Calabria in Italy publishing in The FASEB Journal report that resveratrol blocks the effect of estrogen and can help to prevent the malignant growth of breast cancer in women. The grape/red wine derivative has been the subject of numerous scientific studies in recent years and has shown promise in lowering risks from cardiovascular disease, cancer and dementia.

Scientists also believe the protective nutrient may extend healthy lifespan by directly influencing mortality genes known as SIRT. Italian researchers noted “Resveratrol is a potential pharmacological tool to be exploited when breast cancer become resistant to the hormonal therapy.” Health-minded adults will want to include resveratrol from natural food sources or supplementation to reap the numerous health benefits.

Resveratrol Supplementation Suppresses the Growth of Malignant Breast Cancer Cells

Resveratrol Blocksthe Effect of Estrogen to Help Prevent Breast Cancer

Resveratrol Blocksthe Effect of Estrogen to Help Prevent Breast Cancer

To design their study, researchers used several breast cancer cell lines expressing the estrogen receptor to test the effects of resveratrol. They exposed the different cells to a solution containing resveratrol and compared the results to cells left untreated. They found an important reduction in cell growth in cells treated with resveratrol, while no changes were seen in untreated cells. Further experiments determined that this effect was caused by a critical reduction in estrogen receptors caused by the administration of resveratrol.

This finding is the first of its kind as it relates specifically to the effect of resveratrol on a particular cancer cell line. The team was able to conclude that resveratrol is able to counteract the malignant progression of breast cancer cells by inhibiting the growth and spread of hormone resistant cancerous cells. This has important implications for the treatment of women with breast cancer whose tumors eventually develop resistance to hormonal therapy.

Resveratrol Specifically Targets Cancerous Cells to Fight Breast Cancer

Reseratrol is Commonly Found in Red Wine or Concentrated Supplements

Reseratrol is Commonly Found in Red Wine or Concentrated Supplements

Lead researcher Dr. Sebastiano Ando noted “Resveratrol is a potential pharmacological tool to be exploited when breast cancer become resistant to the hormonal therapy.” A peer review board examining the study data concluded “scientists haven’t finished distilling the secrets of good health that have been hidden in natural products such as red wine.” It is important to note that in this body of research, resveratrol only demonstrated an effect on malignant cancer cells and exerted no effect on non-cancerous cells.

While the authors cautioned that people should not go out and start using red wine or resveratrol supplements as a treatment for breast cancer, the finding strongly indicates that the plant-protective compound should be considered as a component in an overall plan designed to prevent the devastating disease. Nutrition experts recommend a supplemental intake (from a purified, organically derived source) of between 50 and 250 mg per day for optimal health benefits.

h1

Resveratrol and Vitamin D Compliment Weight Management Efforts

November 28, 2011
Natural Nutrient Duo Assists Weight Loss Efforts

Natural Nutrient Duo Assists Weight Loss Efforts

Resveratrol has been on the nutritional radar of researchers because of its proven ability to mimic some of the life-extending characteristics provided by calorie restriction as seen in animals and humans alike. Scientists publishing in the journal Molecular Nutrition and Food Research draw a solid link between resveratrol, vitamin D and other phytonutrients as agents that may lend a helping hand in the life-threatening battle against overweight and obesity.

Researchers document the newly discovered effect of the nature-derived nutrient on lipid metabolism, and demonstrate that supplementation along with the sunshine vitamin and quercetin synergistically decreases the formation of new fat cells in the body. This finding is significant because it may provide a critical metabolic aid to children and adults that suffer the health-damaging effects of obesity every day. Further evidence exists to hail the trio in the genesis of osteoblasts in bone marrow that may offer a new therapy for osteoporosis that affects the mobility of millions of aging adults.

Resveratrol and Vitamin D Combine to Regulate Genes that Control Body Weight

Vitamin D Protects Against New Baby Fat Cell Formation

Vitamin D Protects Against New Baby Fat Cell Formation

Scientists studying metabolism in aging adults have found that stem cells differentiate in favor of adipocytes (fat cells) and to the exclusion of osteoblasts (cells necessary for the formation of new bone). This means that as we age, our body has evolved to store fat as an aid to our survival. As metabolism slows, we continue to eat the same number of calories that helps to fill the newly acquired adipocytes. While building and maintaining bone structure may sound like a good idea to us, it is not pre-programmed into our genetic matrix.

Development of new fat cells has evolved as a protective mechanism, although the vast majority of older adults really don`t need this genetic advantage. Researchers found that supplemented resveratrol, vitamin D and quercetin work together to regulate our genes and down regulate the production of fat cells while boosting the production of osteoblasts. Naturally it is important to practice caloric restriction as we age. Many aging adults will be able to utilize this phytonutrient trio to prevent excess weight gain and the debilitating effects of osteoporosis.

Natural Nutrients Help Weight Management Efforts Along with Healthy Diet

Resveratrol and Vitamin D Synergistically Inhibit Abdominal Adiposity

Resveratrol and Vitamin D Synergistically Inhibit Abdominal Adiposity

In addition to the well documented anti-cancer and longevity benefits previously ascribed to supplemented resveratrol, health-minded individuals will want to include resveratrol and other phytonutrients as an aid in the fight against abdominal fat accumulation. Researchers concluded It should be noted that combining resveratrol with other phytochemicals may provide an extraordinary potential for preventing obesity and osteoporosis. These phytochemical synergies may make possible novel safe, potent and efficacious therapies.” Be sure to include resveratrol (25 to 50 mg per day) in your dietary arsenal to assist weight loss, boost metabolism and prevent bone loss.

h1

Blueberries, Cocoa and Resveratrol Help Weight Loss

August 22, 2011
Natural Compounds From Fruits and Chocolate Assist Weight Loss Efforts

Natural Compounds From Fruits and Chocolate Assist Weight Loss Efforts

A wealth of new scientific evidence shines a critical light on the importance of natural foods and nutritional compounds in the fight against overweight, obesity and weight maintenance. Virtually all alternative health experts agree the current epidemic of weight control issues plaguing western society are the result of excess consumption of highly processed convenience foods that have replaced vegetables, fruits, nuts and seeds in the diet.

Three independent studies conclude that blueberries, resveratrol from red grapes and cocoa flavanols exert a potent effect on fat cell formation that can aid in weight loss and management goals when included as part of your daily diet.

Blueberries Inhibit the Formation of New Baby Fat Cells

Blueberries Inhibit Formation of New Fat Cells for Storage

Blueberries Inhibit Formation of New Fat Cells for Storage

Blueberries have been well documented for their cognitive and cardio-protective benefits, due in large part to the potent complex of anthocyanins that give the berry its deep blue color. Researchers reporting the results of a study to the Experimental Biology 2011 conference have found that blueberries may hold the key to resolving one of the largest threats to human health this century: overweight and obesity.

Scientists determined that extracts of the berry compound inhibited the formation of new baby fat cells (adipocytes) in a dose-dependent manner. Less adipocytes means there are fewer `containers` to store triglycerides from the blood, and ultimately a powerful mechanism to lower or help maintain body weight. Not only did blueberry extract supplementation reduce the number of adipocytes up to 73 percent, but the compound was also found to assist in the breakdown of lipids and fats for removal from the body.

Cocoa Polyphenols Slow the Breakdown of Carbohydrates to Fuel Weight Loss

Cocoa From Dark Chocolate Cuts Carbohydrate Brreakdown to Help Weight Maintenance

Cocoa From Dark Chocolate Cuts Carbohydrate Brreakdown to Help Weight Maintenance

Polyphenols from the cocoa plant have been shown to promote cardiovascular, skin and brain health in recent studies. Research published in the Journal of Agricultural and Food Chemistry provide evidence that extracts of the cacao bean, particularly the flavanol epicatechin is a potent inhibitor of enzymes that break down carbohydrates during digestion.

Study authors determined the compound exerted an effect in a dose-dependent fashion, noting “the more consumed, the greater the effect.” They were also careful to conclude that chocolate and cocoa are two very different terms with the distinction that cocoa is the non-fat component of cocoa liquor, and the carbohydrate-inhibiting effect is not seen when sugar-infused milk chocolate sources are used. A minimum cocoa content of 55% is necessary for health and weight management concerns.

Resveratrol, the bioactive compound found most commonly in the skins of red grapes is shown to reduce body fat formation by preventing the formation of fat tissue in a study published in the journal Nutrition and Metabolism. The compound is known to positively affect cognitive functions and extend natural lifespan by regulating the longevity gene SIRT1. Researchers explain that ingesting resveratrol at supplemental doses (50 mg per day) for a period of six weeks caused a significant reduction in the activity of enzymes linked to fat production in the body.

Effective weight loss and management requires a combination of lifestyle and dietary modifications. Natural foods and dietary nutrients such as blueberries, resveratrol and cocoa compounds provide a safe and powerful mechanism to achieve long-term weight reduction goals.

h1

Grape Compounds Shown to Improve Hypertension in Adults

August 17, 2011
Elevated Blood Pressure is a Key Factor Promoting Early Aging and Disease

Elevated Blood Pressure is a Key Factor Promoting Early Aging and Disease

Adults aged 55 and older face a lifetime risk of developing elevated blood pressure greater than 90%, accounting for more than 40 million doctor visits each year and taxing an already overburdened healthcare system. Uncontrolled blood pressure slowly degrades the vascular system throughout the body and takes a particular toll on the kidneys, eyes and delicate arteries around the heart and in the brain.

Small increases in blood pressure place an individual at dramatically increased risk from heart attack, stroke, kidney failure and blindness. Researchers focusing on the antioxidant capacity of grape seed, resveratrol and pomegranate found that regular consumption of these foods can effectively reduce blood pressure without the need for dangerous prescription drugs.

Natural Fruit Polyphenols Lower Cellular Stress and Blood Pressure

Grape Polyphenols Lowers Oxidative Stress to Lower Blood Pressure

Grape Polyphenols Lowers Oxidative Stress to Lower Blood Pressure

Oxidative stress is a significant factor leading to accelerated damage from hypertension. Excess stress prompts changes to the hormone angiotensin that is known to impact blood pressure through an intricate mechanism of vessel and arterial constriction. Natural agents that can lower dangerous levels of cellular oxidative stress are considered paramount to lowering blood pressure in susceptible individuals.

ACE (angiotensin-converting enzyme)-inhibitors are among the most popular prescription medications prescribed to negate the effect of the angiotensin hormone, and create a life of misery for many due to the myriad of side effects inherent with this class of drug. Recent research shows that artificially lowering blood pressure with drugs has virtually no effect on cardiovascular disease risk, compared to lowering readings with natural fruit polyphenols, diet and physical activity.

Study Shows That Grape Seed Extract and Resveratrol Can Effectively Lower Blood Pressure

Grape Compounds and Pomegranate Combine to Treat Hypertension

Grape Compounds and Pomegranate Combine to Treat Hypertension

Writing in the journal Metabolism, nutritional scientists compared the effect of grape seed extract and resveratrol on subjects with metabolic syndrome. Three groups were divided to receive either grape seed extract (GSE) at a dose of 150 mg per day, GSE at 300 mg per day or a placebo. After 4 weeks, both GSE supplemented groups experienced systolic blood pressure drops of 5 to 7 percent. This change was considered significant as no other dietary or lifestyle interventions were followed. Researchers believe that GSE and grape-derived compounds including resveratrol can be used to prevent and treat hypertension based on the potent antioxidant load delivered by the fruit extracts.

Pomegranates effectively lower blower blood pressure in a manner similar to GSE and resveratrol as the juice and extracts contain powerful polyphenols that counteract oxidative stress. This magical fruit also is found to lower circulating levels of the angiotensin hormone that can help blood vessels to relax. The result of a study published in the journal Atherosclerosis demonstrated that consumption of pomegranate juice (50 ml per day for 2 weeks) lowered ACE activity by 36%, leading to a 5% drop in systolic blood pressure.

It should come as no surprise to those following a natural health lifestyle that the key to controlling blood pressure and reducing the risk factors that promote cardiovascular disease are not found in a prescription bottle. Fruits such as the pomegranate and formulated natural extracts from red grape skins and seeds deliver powerful health benefits without any of the associated side effects of synthesized pharmaceuticals.

h1

Grape Seed Extract and Resveratrol Shown to Halt Diabetes Progression

August 3, 2011
Antioxidant Polyphenols in Grapes Shown to Lower Diabetes Risk

Antioxidant Polyphenols in Grapes Shown to Lower Diabetes Risk

Researchers publishing the results of two independent studies in the British Journal of Nutrition have demonstrated that polyphenol antioxidants found naturally in red grapes can prevent the buildup of fat in muscle tissue that is a precursor to metabolic disorder and diabetes. Resveratrol and grape seed extracts influence how the body responds to insulin, the hormone that controls critical mechanisms of dietary sugar and fat metabolism.

The grape-derived compounds have been shown to improve cardiovascular and Alzheimer`s disease risk factors in the past. Information gleaned from these studies explains how daily consumption of the fresh fruit can be invaluable as it prevents muscular fat accumulation leading to metabolic instability and diabetes.

High Sugar Diet Leads to Fat Accumulation in Muscle Tissue

Consuming High Sugar Foods Causes Fat Deposits in Muscle Tissue

Consuming High Sugar Foods Causes Fat Deposits in Muscle Tissue

Detailing the result of research performed at the University of Montpellier in France, scientists found that subjects fed a diet high in fat and sugar experienced a lower accumulation of fat in muscle tissue when supplemented with a concentrated extract of red grape polyphenols. Diets high in oxidized saturated fats are known to disrupt the normal function of insulin leading to insulin resistance and diabetes. By limiting the effect of fats on cell membranes, the grape extract was found to provide a significant level of protection against the disease.

In a separate body of research, scientists determined that a 10 mg daily dose of resveratrol was associated with lowered insulin resistance in Type-II diabetics. Resveratrol is a powerful protective anti-fungal compound found in the skin of red grapes. Known to activate a longevity signaling gene (SIRT-1), resveratrol has been shown to extend lifespan by lowering the risks associated with systemic inflammation. The polyphenol may help to prevent cancer development, cardiovascular disease and dementia, and is now shown to impede the development of diabetes by regulating insulin sensitivity.

Resveratrol Improves Insulin Sensitivity to Prevent Metabolic Syndrome and Diabetes

Resveratrol From Supplements and Red Wine Improves Insulin Sensitivity

Resveratrol From Supplements and Red Wine Improves Insulin Sensitivity

Researchers formed two groups of participants and randomly supplemented their diet with resveratrol (5 mg twice a day) or a placebo. After four weeks the resveratrol group showed a significant decrease in insulin sensitivity compared to the placebo group. The study authors explain that the results are likely due to the potent antioxidant action of resveratrol, as oxidative stress is a key contributor to the onset of insulin resistance.

Researchers concluded “The present study shows for the first time that resveratrol improves insulin sensitivity in humans, which might be due to a resveratrol-induced decrease in oxidative stress that leads to more efficient insulin signaling.” To maximize the anti-diabetic health benefits of grape polyphenols, health-minded individuals will want to include organically grown red grapes in their diet or supplement with grape seed extract and resveratrol (10 to 25 mg daily).